HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → Raloxifene
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Raloxifene Hydrochloride | HCID 54900 | — |
| Reactant | Linolenoyl chloride | HCID 5702742 | — |
| Catalyst | 4-(Dimethylamino)pyridine | HCID 14284 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | Raloxifene | HCID 5035 | — |
Reaction Steps
This derivative was prepared in a manner similar to Example 1, using 2.6 g (0.005 mol) of Raloxifene HCl, 2 g (0.02 mol) of triethylamine, 20 mg of DMAP, and 3.2 g (0.01 mol) of linolenoyl chloride in 250 mL of THF. The final product was chromatographed on a silica gel column eluted with EtOAc-hexane (8:2). This yielded 3.21 g of the title compound as clear oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05929092 |
| Source dataset | uspto-grants-1999_07 |
| ORD ID | ord-b83cb7783d2f4c4b9d00bd785d518b9b |
| Source note | uspto-grants-1999_07 |