4-Formylphenylboronic Acid → HCID 86591268, compound

HRID 584956

Reaction equation

HRID 584956 reaction equation
Br[C:2]1[CH:3]=[C:4]([CH:15]=[CH:16][CH:17]=1)[CH2:5][N:6]([CH3:14])[C:7](=[O:13])[O:8][C:9]([CH3:12])([CH3:11])[CH3:10].[CH:18]([C:20]1[CH:25]=[CH:24][C:23](B(O)O)=[CH:22][CH:21]=1)=[O:19]>>[CH:18]([C:20]1[CH:25]=[CH:24][C:23]([C:2]2[CH:17]=[CH:16][CH:15]=[C:4]([CH2:5][N:6]([CH3:14])[C:7](=[O:13])[O:8][C:9]([CH3:12])([CH3:11])[CH3:10])[CH:3]=2)=[CH:22][CH:21]=1)=[O:19]

Participants

3

Reactant 2

HCID 5910734-Formylphenylboronic AcidHCID 20738487tert-Butyl 3-bromobenzyl(methyl)carbamate

Product 1

HCID 86591268HCID 86591268, compoundYield 67.5%

Procedure

In a manner similar to that of Example 1(e), starting with 125 g (410 mmol) of tert-butyl (3-bromo benzyl)-N-methylcarbamate (prepared in Example 1(b)) and 82 g (510 mmol) of 4-formylbenzene boronic acid, 90 g (67%) of the desired product are obtained.

Sources & evidence

ORD record
ord-b68d939be62d4d5897d9b42d22588fba
Source dataset
uspto-grants-2005_08
Patent number
US06927228B2

Linked notes

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