6,6-Dimethyl-5,7-dioxaspiro(2.5)octane-4,8-dione → 2-Oxo-1-(4-(trifluoromethoxy)phenyl)pyrrolidine-3-carboxylic acid

HRID 58576

Reaction equation

HRID 58576 reaction equation
CC1(C)[O:9][C:8](=[O:10])[C:5]2([CH2:7][CH2:6]2)[C:4](=[O:11])O1.[F:13][C:14]([F:24])([F:23])[O:15][C:16]1[CH:22]=[CH:21][C:19]([NH2:20])=[CH:18][CH:17]=1>C(O)C>[O:11]=[C:4]1[CH:5]([C:8]([OH:9])=[O:10])[CH2:7][CH2:6][N:20]1[C:19]1[CH:21]=[CH:22][C:16]([O:15][C:14]([F:13])([F:23])[F:24])=[CH:17][CH:18]=1

Participants

4

Reactant 2

HCID 797206,6-Dimethyl-5,7-dioxaspiro(2.5)octane-4,8-dioneHCID 6008484-(Trifluoromethoxy)aniline

Product 1

HCID 246893612-Oxo-1-(4-(trifluoromethoxy)phenyl)pyrrolidine-3-carboxylic acidYield 82.3%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

This compound was prepared according to general method 1 starting from 6,6-dimethyl-5,7-dioxaspiro[2.5]octane-4,8-dione (0.250 g, 1.47 mmol) and 4-(trifluoromethoxy)aniline (0.595 mL; 4.41 mmol) in ethanol (3 mL). 2-oxo-1-(4-(trifluoromethoxy)phenyl)pyrrolidine-3-carboxylic acid 0.350 g (82%) was obtained as a yellow solid.

Workup

  1. customThis compound was prepared

Sources & evidence

ORD record
ord-56b333c44e0549008827d4b10428caf3
Source dataset
uspto-grants-2016_09
Patent number
US09434722B2

Linked notes

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