2,6-Difluoroaniline → 1-(2,6-Difluorophenyl)-2-oxopyrrolidine-3-carboxylic acid

HRID 58590

Reaction equation

HRID 58590 reaction equation
CC1(C)[O:9][C:8](=[O:10])[C:5]2([CH2:7][CH2:6]2)[C:4](=[O:11])O1.[F:13][C:14]1[CH:20]=[CH:19][CH:18]=[C:17]([F:21])[C:15]=1[NH2:16]>C(O)C>[F:13][C:14]1[CH:20]=[CH:19][CH:18]=[C:17]([F:21])[C:15]=1[N:16]1[CH2:6][CH2:7][CH:5]([C:8]([OH:9])=[O:10])[C:4]1=[O:11]

Participants

4

Reactant 2

HCID 796472,6-DifluoroanilineHCID 797206,6-Dimethyl-5,7-dioxaspiro(2.5)octane-4,8-dione

Product 1

HCID 242752521-(2,6-Difluorophenyl)-2-oxopyrrolidine-3-carboxylic acidYield 46%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

This compound was prepared according to general method 1 starting from 6,6-dimethyl-5,7-dioxaspiro[2.5]octane-4,8-dione (0.250 g; 1.45 mmol) and 2,6-difluoroaniline (0.575 g; 4.36 mmol) in ethanol (3 mL). 1-(2,6-difluorophenyl)-2-oxopyrrolidine-3-carboxylic acid 0.161 g (46%) was obtained as a solid.

Workup

  1. customThis compound was prepared

Sources & evidence

ORD record
ord-403f6f210d654a6da0ce8deb6b58b2e6
Source dataset
uspto-grants-2016_09
Patent number
US09434722B2

Linked notes

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