p-tert-Butylacetophenone → 1-(4-Tert-butylphenyl)ethan-1-amine

Reaction equation

C(C1C=CC(C(=O)C)=CC=1)(C)(C)C.[C:14]([C:18]1[CH:23]=[CH:22][C:21]([CH:24]([NH:26]C(NC2C=CC=C3C=2C=CN=C3)=O)[CH3:25])=[CH:20][CH:19]=1)([CH3:17])([CH3:16])[CH3:15]>>[C:14]([C:18]1[CH:19]=[CH:20][C:21]([CH:24]([NH2:26])[CH3:25])=[CH:22][CH:23]=1)([CH3:17])([CH3:15])[CH3:16]

Participants

Reactant 2

HCID 13669p-tert-Butylacetophenone

HCID 9975006N-[1-(4-tert-butylphenyl)ethyl]-N'-5-isoquinolinylurea

Product 1

HCID 51009801-(4-Tert-butylphenyl)ethan-1-amine

Procedure

The title compound was prepared using 1-(4-tert-butylphenyl)ethanone and the procedures described in Examples 136A and 136B Example 140B N-[1-(4-tert-butylphenyl)ethyl]-N′-5-isoquinolinylurea

Sources & evidence

ORD record: ord-cee4d89b8023470e89e1cdcced833cdb
Source dataset: uspto-grants-2005_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06933311B2

Reaction notes

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