HCID 22337641, compound → HCID 22337569, compound
Reaction equation
[C:1]([O:4][C:5]1[N:6]=[CH:7][C:8]2[C:13]([CH:14]=1)=[C:12]([N+:15]([O-])=O)[CH:11]=[CH:10][CH:9]=2)(=[O:3])[CH3:2].[H][H]>O1CCOCC1.[Ni]>[C:1]([O:4][C:5]1[N:6]=[CH:7][C:8]2[C:13]([CH:14]=1)=[C:12]([NH2:15])[CH:11]=[CH:10][CH:9]=2)(=[O:3])[CH3:2]Participants
5
Reactant 2
Product 1
Reagents, catalysts & solvents 2
Procedure
5-Nitro-3-isoquinolinyl acetate (50 mg, 0.21 mmol) in 1,4-dioxane (20 mL) was treated with Raney-nickel powder (85 mg) and exposed to a hydrogen atmosphere via a balloon for 16 hours. The mixture was filtered through a plug of Celite and the filtrate was concentrated under reduced pressure to provide the title compound which was used without further purification.
Workup
- filtrationThe mixture was filtered through a plug of Celite
- concentrationthe filtrate was concentrated under reduced pressure
Sources & evidence
- ORD record
- ord-6030cf523eb1485b8d630bbd1dfbbf4a
- Source dataset
- uspto-grants-2005_08
- Patent number
- US06933311B2
Reaction notes
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