2-(Methoxymethyl)piperidine hydrochloride → rac-3-[(4-(2-Methoxymethylpiperidin-1-yl)-1,3,5-triazin-2-yl)amino]-benzenemethanesulfonamide

HRID 587141

Reaction equation

HRID 587141 reaction equation
F[C:2]1(F)[CH2:7][CH2:6][N:5]([C:8]2[N:13]=[CH:12][N:11]=[C:10]([NH:14][C:15]3[CH:16]=[C:17]([CH2:21][S:22]([NH2:25])(=[O:24])=[O:23])[CH:18]=[CH:19][CH:20]=3)[N:9]=2)[CH2:4][CH2:3]1.ClC1N=CN=C(NC2C=C(CS(N)(=O)=O)C=CC=2)N=1.Cl.[CH3:47][O:48][CH2:49]C1CCCCN1>>[CH3:47][O:48][CH2:49][CH:6]1[CH2:7][CH2:2][CH2:3][CH2:4][N:5]1[C:8]1[N:13]=[CH:12][N:11]=[C:10]([NH:14][C:15]2[CH:16]=[C:17]([CH2:21][S:22]([NH2:25])(=[O:24])=[O:23])[CH:18]=[CH:19][CH:20]=2)[N:9]=1

Participants

4

Reactant 3

HCID 459261592-(Methoxymethyl)piperidine hydrochlorideHCID 601971023-[(4-(4,4-Difluoropiperidin-1-yl)-1,3,5-triazin-2-yl)amino]-benzenemethanesulfonamideHCID 866798223-[(4-Chloro-1,3,5-triazin-2-yl)amino]benzenemethanesulfonamide

Product 1

HCID 60197106rac-3-[(4-(2-Methoxymethylpiperidin-1-yl)-1,3,5-triazin-2-yl)amino]-benzenemethanesulfonamide

Procedure

B4 was prepared following the procedure reported for B2 using A1 and rac-2-methoxymethylpiperidine hydrochloride. The title compound was purified by thick-layer chromatography (silica gel, chloroform/MeOH 19:1) and obtained as a white crystalline solid; yield: 235 mg (67%). MS (ES) C17H24N6O3S requires: 392. found: 393 (M+H)+.

Workup

  1. customThe title compound was purified by thick-layer chromatography (silica gel, chloroform/MeOH 19:1)
  2. customobtained as a white crystalline solid

Sources & evidence

ORD record
ord-db7379088f3d4dcca8d5b74f80ebf560
Source dataset
uspto-grants-2016_01
Patent number
US09226929B2

Linked notes

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