tert-butyl N-((piperidin-2-yl)methyl)carbamate → Tert-butyl [(1-(4-((3-(sulfamoylmethyl)phenyl)amino)-1,3,5-triazin-2-yl)piperidine-2-yl)methyl]carbamate

HRID 587143

Reaction equation

HRID 587143 reaction equation
COC[CH:4]1[CH2:9][CH2:8][CH2:7][CH2:6][N:5]1[C:10]1[N:15]=[CH:14][N:13]=[C:12]([NH:16][C:17]2[CH:18]=[C:19]([CH2:23][S:24]([NH2:27])(=[O:26])=[O:25])[CH:20]=[CH:21][CH:22]=2)[N:11]=1.ClC1N=CN=C(NC2C=C(CS(N)(=O)=O)C=CC=2)N=1.N1CCCCC1[CH2:53][NH:54][C:55](=[O:61])[O:56][C:57]([CH3:60])([CH3:59])[CH3:58]>>[C:57]([O:56][C:55](=[O:61])[NH:54][CH2:53][CH:4]1[CH2:9][CH2:8][CH2:7][CH2:6][N:5]1[C:10]1[N:11]=[C:12]([NH:16][C:17]2[CH:22]=[CH:21][CH:20]=[C:19]([CH2:23][S:24](=[O:26])(=[O:25])[NH2:27])[CH:18]=2)[N:13]=[CH:14][N:15]=1)([CH3:60])([CH3:59])[CH3:58]

Participants

4

Reactant 3

HCID 2756031tert-butyl N-((piperidin-2-yl)methyl)carbamateHCID 60197106rac-3-[(4-(2-Methoxymethylpiperidin-1-yl)-1,3,5-triazin-2-yl)amino]-benzenemethanesulfonamideHCID 866798223-[(4-Chloro-1,3,5-triazin-2-yl)amino]benzenemethanesulfonamide

Product 1

HCID 60197197Tert-butyl [(1-(4-((3-(sulfamoylmethyl)phenyl)amino)-1,3,5-triazin-2-yl)piperidine-2-yl)methyl]carbamate

Procedure

B7 was prepared following the procedure reported for B4 using A1 and rac-tert-butyl (piperidin-2-yl)methylcarbamate and obtained as a white crystalline solid; yield: 280 mg (65%). MS (ES) C21H31N7O4S requires: 477. found: 478 (M+H)+.

Workup

  1. customobtained as a white crystalline solid

Sources & evidence

ORD record
ord-f379f6e7cd824fd297cc9dee8346742e
Source dataset
uspto-grants-2016_01
Patent number
US09226929B2

Linked notes

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