(R)-(-)-1-(2-Pyrrolidinylmethyl)pyrrolidine → HCID 60197503, compound

HRID 587164

Reaction equation

HRID 587164 reaction equation
COCC1CCCCN1C1N=CN=C(NC2C=C(CS(N)(=O)=O)C=CC=2)N=1.Cl[C:29]1[N:34]=[CH:33][N:32]=[C:31]([NH:35][C:36]2[CH:37]=[C:38]([CH2:42][S:43]([NH2:46])(=[O:45])=[O:44])[CH:39]=[CH:40][CH:41]=2)[N:30]=1.[N:47]1([CH2:52][C@H:53]2[CH2:57][CH2:56][CH2:55][NH:54]2)[CH2:51][CH2:50][CH2:49][CH2:48]1>>[N:47]1([CH2:52][C@H:53]2[CH2:57][CH2:56][CH2:55][N:54]2[C:29]2[N:34]=[CH:33][N:32]=[C:31]([NH:35][C:36]3[CH:37]=[C:38]([CH2:42][S:43]([NH2:46])(=[O:45])=[O:44])[CH:39]=[CH:40][CH:41]=3)[N:30]=2)[CH2:51][CH2:50][CH2:49][CH2:48]1

Participants

4

Reactant 3

HCID 853151(R)-(-)-1-(2-Pyrrolidinylmethyl)pyrrolidineHCID 60197106rac-3-[(4-(2-Methoxymethylpiperidin-1-yl)-1,3,5-triazin-2-yl)amino]-benzenemethanesulfonamideHCID 866798223-[(4-Chloro-1,3,5-triazin-2-yl)amino]benzenemethanesulfonamide

Product 1

HCID 60197503HCID 60197503, compound

Procedure

B31 was prepared following the procedure reported for B4 using A1 and (R)-2-((pyrrolidin-1-yl)methyl)pyrrolidine. It was obtained as a white crystalline solid; yield: 65 mg (17%). MS (ES) C19H27N7O2S requires: 417. found: 418 (M+H)+.

Workup

  1. customB31 was prepared
  2. customIt was obtained as a white crystalline solid

Sources & evidence

ORD record
ord-5623d10c54154f13b44b8c89c7aaefce
Source dataset
uspto-grants-2016_01
Patent number
US09226929B2

Linked notes

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