Triethyl phosphite → HCID 12565589, compound

Reaction equation

Br[CH:2]([CH2:7][CH3:8])[C:3]([O:5][CH3:6])=[O:4].[CH2:9]([O:11][P:12]([O:16]CC)[O:13][CH2:14][CH3:15])[CH3:10]>>[CH3:6][O:5][C:3](=[O:4])[CH:2]([P:12]([O:13][CH2:14][CH3:15])([O:11][CH2:9][CH3:10])=[O:16])[CH2:7][CH3:8]

Participants

Reactant 2

HCID 31215Triethyl phosphite

HCID 95577Butanoic acid, 2-bromo-, methyl ester

Product 1

HCID 12565589HCID 12565589, compound

Conditions

Temperature: 110 °C

Procedure

Methyl 2-bromobutanoate (92 g, 0.508 mol) and triethylphosphite (95 g, 0.57 mol) were mixed, and the mixture was stirred at 110° C. for 3 days. The reaction mixture was dried under reduced pressure to give the title compound.

Workup

customThe reaction mixture was dried under reduced pressure

Sources & evidence

ORD record: ord-e4d9383d4afb4a1aa648a281f2c23751
Source dataset: uspto-grants-2016_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09227949B2

Reaction notes

Loading…