3-Fluoroazetidine → HCID 71538685, compound

HRID 588448

Reaction equation

[F:1][CH:2]1[CH2:5][NH:4][CH2:3]1.[CH3:6][N:7]([CH3:29])[C:8]1[N:28]=[C:11]2[CH:12]=[CH:13][C:14]([NH:16][C:17]([C:19]3[N:23]([CH3:24])[N:22]=[CH:21][C:20]=3[C:25](O)=[O:26])=[O:18])=[CH:15][N:10]2[N:9]=1>>[CH3:6][N:7]([CH3:29])[C:8]1[N:28]=[C:11]2[CH:12]=[CH:13][C:14]([NH:16][C:17]([C:19]3[N:23]([CH3:24])[N:22]=[CH:21][C:20]=3[C:25]([N:4]3[CH2:5][CH:2]([F:1])[CH2:3]3)=[O:26])=[O:18])=[CH:15][N:10]2[N:9]=1

Participants

Reactant 2

HCID 36035423-Fluoroazetidine

HCID 89464053HCID 89464053, compound

Product 1

HCID 71538685HCID 71538685, compound

Procedure

Using 3-fluoro-azetidine and 5-(2-dimethylamino-[1,2,4]triazolo[1,5-a]pyridin-6-ylcarbamoyl)-1-methyl-1H-pyrazole-4-carboxylic acid, the title compound was prepared in the same manner as described for example 2. Light yellow solid (160 mg, 68%). MS: m/z=387 (M+H+).

Sources & evidence

ORD record: ord-1347a8e82da8411cb4a9e5f19825eab1
Source dataset: uspto-grants-2016_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09227970B2

Linked notes

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