2-Pyrrolidin-1-yl-[1,2,4]triazolo[1,5-a]pyridin-6-ylamine → 1-Methyl-5-(2-pyrrolidin-1-yl-[1,2,4]triazolo[1,5-a]pyridin-6-ylcarbamoyl)-1H-pyrazole-4-carboxylic acid ethyl ester

HRID 588458

Reaction equation

HRID 588458 reaction equation
N1(C2N=C3C=CC(N)=CN3N=2)CCCC1.[CH2:16]([O:18][C:19]([C:21]1[CH:22]=[N:23][N:24]([CH3:44])[C:25]=1[C:26](=[O:43])[NH:27][C:28]1[CH:29]=[CH:30][C:31]2[N:32]([N:34]=[C:35]([N:37]3[CH2:42][CH2:41]O[CH2:39][CH2:38]3)[N:36]=2)[CH:33]=1)=[O:20])[CH3:17]>>[CH2:16]([O:18][C:19]([C:21]1[CH:22]=[N:23][N:24]([CH3:44])[C:25]=1[C:26](=[O:43])[NH:27][C:28]1[CH:29]=[CH:30][C:31]2[N:32]([N:34]=[C:35]([N:37]3[CH2:42][CH2:41][CH2:39][CH2:38]3)[N:36]=2)[CH:33]=1)=[O:20])[CH3:17]

Participants

3

Reactant 2

HCID 894638012-Pyrrolidin-1-yl-[1,2,4]triazolo[1,5-a]pyridin-6-ylamineHCID 894647211-methyl-5-(2-morpholin-4-yl-[1,2,4]triazolo[1,5-a]pyridin-6-ylcarbamoyl)-1H-pyrazole-4-carboxylic acid ethyl ester

Product 1

HCID 894645911-Methyl-5-(2-pyrrolidin-1-yl-[1,2,4]triazolo[1,5-a]pyridin-6-ylcarbamoyl)-1H-pyrazole-4-carboxylic acid ethyl ester

Procedure

Using 2-Pyrrolidin-1-yl-[1,2,4]triazolo[1,5-a]pyridin-6-ylamine, this compound was prepared following the same method as for the synthesis of 1-methyl-5-(2-morpholin-4-yl-[1,2,4]triazolo[1,5-a]pyridin-6-ylcarbamoyl)-1H-pyrazole-4-carboxylic acid ethyl ester. Brown solid (1.1 g, 65%). MS: m/z=384 (M+H+).

Workup

  1. customthis compound was prepared

Sources & evidence

ORD record
ord-268881cf76e542e1bcc266f70ca47ef8
Source dataset
uspto-grants-2016_01
Patent number
US09227970B2

Linked notes

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