N-Iodosuccinimide → CID 86717264
Reaction equation
[Cl:1][C:2]1[C:7]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)=[N:6][N:5]=[C:4]2[NH:14][N:15]=[CH:16][C:3]=12.[I:17]N1C(=O)CCC1=O>C(#N)C>[Cl:1][C:2]1[C:7]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)=[N:6][N:5]=[C:4]2[NH:14][N:15]=[C:16]([I:17])[C:3]=12Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
A suspension of 4-chloro-5-phenyl-1H-pyrazolo[3,4-c]pyridazine (2.44 g, 10.6 mmol) and N-iodosuccinimide (3.58 g, 15.9 mmol) in acetonitrile (106 mL) was heated at reflux for 1 d. The yellow solid was collected by filtration whilst warm to provide a mixture of the title compound and starting material (9:1, 4 g).
Workup
- temperaturewas heated
- temperatureat reflux for 1 d
- filtrationThe yellow solid was collected by filtration
- temperaturewhilst warm
- customto provide
Sources & evidence
- ORD record
- ord-6315fa9e8ee64983b46b55d62701630f
- Source dataset
- uspto-grants-2016_01
- Patent number
- US09227976B2
Reaction notes
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