HCID 86603565, compound → Imidazo[1,2-a]pyrazin-2-amine
Reaction equation
FC(F)(F)C([NH:5][C:6]1[N:7]=[C:8]2[CH:13]=[N:12][CH:11]=[CH:10][N:9]2[CH:14]=1)=O>N.CO>[N:7]1[C:6]([NH2:5])=[CH:14][N:9]2[CH:10]=[CH:11][N:12]=[CH:13][C:8]=12Participants
4
Reagents, catalysts & solvents 2
Conditions
- Temperature
- 68 °C
Procedure
2,2,2-Trifluoro-N-(imidazo[1,2-a]pyrazin-2-yl)acetamide (prepared as described in WO2004/058266A1, 520 mg) was dissolved in 7N NH3 in methanol (4.0 mL), and heated at 68° C. in a sealed tube for 6 hours. The reaction mixture was then cooled and concentrated to provide the title compound.
Workup
- temperatureThe reaction mixture was then cooled
- concentrationconcentrated
Sources & evidence
- ORD record
- ord-c5564128c32a40b78dc3757ec35a306a
- Source dataset
- uspto-grants-2016_01
- Patent number
- US09227963B2
Reaction notes
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