Bromine → HCID 86732529, compound

HRID 589026

Reaction equation

HRID 589026 reaction equation
[Br:1]Br.[O:3]=[C:4]([C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][N:12]=1)[CH2:5][C:6]([O:8][CH2:9][CH3:10])=[O:7]>C(Cl)(Cl)Cl>[BrH:1].[Br:1][CH:5]([C:4](=[O:3])[C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][N:12]=1)[C:6]([O:8][CH2:9][CH3:10])=[O:7]

Participants

4

Reactant 2

HCID 24408BromineHCID 2736461Ethyl 3-oxo-3-(pyridin-2-yl)propanoate

Product 1

HCID 86732529HCID 86732529, compoundYield 196.1%

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent2×

Procedure

Bromine (0.83 g, 5.2 mmol) in chloroform (2 mL) was added slowly to a solution of ethyl 3-oxo-3-pyridin-2-ylpropanoate (1.0 g, 5.2 mmol) and chloroform (25.0 mL) at room temperature. The reaction mixture was stirred for 1 h and was concentrated under reduced pressure to give 1 ethyl 2-bromo-3-oxo-3-pyridin-2-ylpropanoate hydrobromide salt as an amber oil (1.8 g, 100%). LCMS calc. for C10H11BrNO3 (M+H)+: m/z=272.0, 274.0. found: 272.0, 274.0.

Workup

  1. concentrationwas concentrated under reduced pressure

Sources & evidence

ORD record
ord-0329859aee474515871bea3be49a8efd
Source dataset
uspto-grants-2016_01
Patent number
US09227985B2

Linked notes

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