Ethanol → HCID 178470794, compound
Reaction equation
[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3]([CH2:10][C:11]([OH:13])=[O:12])=[N:2]1.[CH2:14](O)[CH3:15]>>[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3]([CH2:10][C:11]([O:13][CH2:14][CH3:15])=[O:12])=[N:2]1Participants
3
Procedure
2-(1H-indazol-3-yl)acetic acid (3.9 g, 22.1 mmol) was dissolved in anhydrous ethanol (100 mL) concentrated sulfuric acid (5 mL), and heated under reflux for 16 hours. It was concentrated under reduce pressure to remove most of ethanol, then water (30 mL) was added, and extracted with ethyl acetate. The organic phase was dried over anhydrous sodium sulfate, concentrated to obtain the product 3.96 g, at a yield of 87.8%.
Workup
- temperatureheated
- temperatureunder reflux for 16 hours
- concentrationIt was concentrated
- customto remove most of ethanol
- additionwater (30 mL) was added
- extractionextracted with ethyl acetate
- dry with materialThe organic phase was dried over anhydrous sodium sulfate
- concentrationconcentrated
Sources & evidence
- ORD record
- ord-dd0e378a617d43fc844ce584449dd079
- Source dataset
- uspto-grants-2016_01
- Patent number
- US09233098B2
Reaction notes
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