2,4-Dichloro-5-methylbenzene-1-sulphonyl chloride → 2,4-Dichloro-5-methyl-N-[3-(1H-tetrazol-5-yl)phenyl]benzenesulfonamide

HRID 589722Notes

Reaction equation

HRID 589722 reaction equation
[Cl:1][C:2]1[CH:7]=[C:6]([Cl:8])[C:5]([CH3:9])=[CH:4][C:3]=1[S:10](Cl)(=[O:12])=[O:11].[NH2:14][C:15]1[CH:16]=[C:17]([C:21]2[NH:25][N:24]=[N:23][N:22]=2)[CH:18]=[CH:19][CH:20]=1>>[Cl:1][C:2]1[CH:7]=[C:6]([Cl:8])[C:5]([CH3:9])=[CH:4][C:3]=1[S:10]([NH:14][C:15]1[CH:20]=[CH:19][CH:18]=[C:17]([C:21]2[NH:25][N:24]=[N:23][N:22]=2)[CH:16]=1)(=[O:12])=[O:11]

Participants

3

Reactant 2

HCID 1199142,4-Dichloro-5-methylbenzene-1-sulphonyl chlorideHCID 178507542HCID 178507542, compound

Product 1

HCID 1784297332,4-Dichloro-5-methyl-N-[3-(1H-tetrazol-5-yl)phenyl]benzenesulfonamideYield 24.5%

Procedure

The product was prepared according to General Procedure 1, described in Example 1, starting with 2,4-dichloro-5-methylbenzene sulfonyl chloride (14.3 mg, 0.055 mmol) and 5-(3-aminophenyl)tetrazole (8 mg, 0.05 mmol) yielding 4.7 mg (24%) of the title compound. MS (ESI+) calcd for C14H11Cl2N5O2S 383.001051, found 383.000871.

Workup

  1. customThe product was prepared

Sources & evidence

ORD record
ord-13b2b43df69d4b1eacfd6f2aa3df9427
Source dataset
uspto-grants-2016_01
Patent number
US09233946B2

Reaction notes

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