Cyclopropanesulfonyl chloride → HCID 57989693, compound
Reaction equation
[Cl:1][C:2]1[N:7]=[C:6]([C:8]2[S:12][C:11]([CH:13]([CH3:15])[CH3:14])=[N:10][C:9]=2[C:16]2[CH:17]=[CH:18][C:19](F)=[C:20]([NH2:22])[CH:21]=2)[CH:5]=[CH:4][N:3]=1.[CH:24]1([S:27](Cl)(=[O:29])=[O:28])[CH2:26][CH2:25]1>>[Cl:1][C:2]1[N:7]=[C:6]([C:8]2[S:12][C:11]([CH:13]([CH3:15])[CH3:14])=[N:10][C:9]=2[C:16]2[CH:21]=[C:20]([NH:22][S:27]([CH:24]3[CH2:26][CH2:25]3)(=[O:29])=[O:28])[CH:19]=[CH:18][CH:17]=2)[CH:5]=[CH:4][N:3]=1Participants
3
Procedure
Following a procedure analogous to the procedure described in Intermediate 14 using {5-[5-(2-chloro-4-pyrimidinyl)-2-(1-methylethyl)-1,3-thiazol-4-yl]-2-fluorophenyl}amine (283 mg, 0.811 mmol) and cyclopropanesulfonyl chloride (114 mg, 0.811 mmol) the title compound was obtained as a white solid (247 mg, 67% yield). MS (ESI): 453.3 [M+H]+.
Sources & evidence
- ORD record
- ord-02ca4f56572443228b5e08d405e94955
- Source dataset
- uspto-grants-2016_01
- DOI