HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzoyl Peroxide → 3-Bromo-2-(4-chlorobenzylidene)indan-1-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzoyl Peroxide | HCID 7187 | — |
| Reactant | N-bromobutanimide | HCID 67184 | — |
| Reactant | 2-(p-Chlorobenzylidene)-1-indanone | HCID 367217 | — |
| Solvent | Carbon Tetrachloride | HCID 5943 | — |
| Product | 3-Bromo-2-(4-chlorobenzylidene)indan-1-one | HCID 68748582 | — |
Reaction Steps
2-(4-chlorobenzylidene)indan-1-one (2.44 g, 9.58 mmol) was dissolved in 35 mL of CCl4. N-bromosuccinimide (1.685 g, 9.58 mmol) and benzoyl peroxide (122 mg, 0.52 mmol) were added in one portion. The solution was then stirred under reflux for one hour and then filtered once cooled to room temperature. The precipitate was separated using flash column chromatography (15:1 Hexanes/EtOAc) provided 14a as white crystals.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09439877B2 |
| Source dataset | uspto-grants-2016_09 |
| ORD ID | ord-814d39fdb22b4d17948eb2814524dcdd |
| Source note | uspto-grants-2016_09 |