tert-Butyl (4-((2,3-diaminopyridin-4-yl)oxy)-2-fluorophenyl)carbamate → Tert-butyl 4-(2,3-diaminopyridin-4-yloxy)naphthalen-1-ylcarbamate
Reaction equation
[C:1]([O:5][C:6](=[O:29])[NH:7][C:8]1[C:17]2[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=2)[C:11]([O:18][C:19]2[CH:24]=[CH:23][N:22]=[C:21]([NH2:25])[C:20]=2[N+:26]([O-])=O)=[CH:10][CH:9]=1)([CH3:4])([CH3:3])[CH3:2].NC1C(N)=C(OC2C=CC(NC(=O)OC(C)(C)C)=C(F)C=2)C=CN=1>>[C:1]([O:5][C:6](=[O:29])[NH:7][C:8]1[C:17]2[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=2)[C:11]([O:18][C:19]2[CH:24]=[CH:23][N:22]=[C:21]([NH2:25])[C:20]=2[NH2:26])=[CH:10][CH:9]=1)([CH3:4])([CH3:2])[CH3:3]Participants
3
Procedure
The title compound was prepared from tert-butyl-4-(2-amino-3-nitropyridin-4-yl-oxy)naphthalen-1-yl-carbamate (3b) (0.50 g, 1.26 mmol) by the same method as described for compound (4a) as a brown solid.
Sources & evidence
- ORD record
- ord-2692d82b721541f8841be8a97638448f
- Source dataset
- uspto-grants-2016_09
- Patent number
- US09439893B2
Reaction notes
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