Methylglyoxal → HCID 178430963, compound
Reaction equation
[NH2:1][CH2:2][C:3]([NH:5][OH:6])=[O:4].CO.[CH3:9][C:10]([CH:12]=O)=O.[OH-].[Na+]>O>[CH3:12][C:10]1[CH:9]=[N+:5]([O-:6])[C:3]([OH:4])=[CH:2][N:1]=1Participants
6
Reactant 4
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 5 °C
Procedure
100 mmol (9 g) glycine hydroxamic acid were cooled to −25° C. in 200 ml water and methanol each, 100 mmol (15.4 ml 40% solution) methylglyoxal were added dropwise and subsequently the pH was adjusted to approximately pH 11 with 10 ml 30% NaOH. Heating up to 5° C. was carried out in 2 h and concentrated under vacuum to half of the solvent volume. A pH 3 was adjusted with 20% HCl, precipitated solid was filtered off and dried. 7.28 g (52% yield) of the title compound were obtained.
Workup
- concentrationconcentrated under vacuum to half of the solvent volume
- customprecipitated solid
- filtrationwas filtered off
- customdried
Sources & evidence
- ORD record
- ord-4d7c9ee2a2db4964a663905b500c8598
- Source dataset
- uspto-grants-2016_09
- Patent number
- US09439910B2
Reaction notes
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