Methanol → Methyl 3-amino-2-methylpropanoate hydrochloride

HRID 590560

Reaction equation

HRID 590560 reaction equation
[CH3:1][CH:2]([C:5]([OH:7])=[O:6])[CH2:3][NH2:4].O=S(Cl)[Cl:10].[CH3:12]O>>[ClH:10].[NH2:4][CH2:3][CH:2]([CH3:1])[C:5]([O:7][CH3:12])=[O:6]

Participants

4

Reactant 3

HCID 887MethanolHCID 24386Thionyl ChlorideHCID 64956Beta-Aminoisobutyric Acid

Product 1

HCID 13063725Methyl 3-amino-2-methylpropanoate hydrochloride

Procedure

To the solution of DL-3-aminoisobutyric acid (CAS number: 144-90-1, Aldrich) (2.7 g, 26.4 mmol) in MeOH (50 mL) was added SOCl2 (6.17 g, 52.8 mmol) dropwise at 0° C. under N2 atmosphere. The reaction was refluxed for 18 hours. The solvent was removed in vacuo to give crude Compound W which was used directly in the next step.

Workup

  1. temperatureThe reaction was refluxed for 18 hours
  2. customThe solvent was removed in vacuo

Sources & evidence

ORD record
ord-3bdec371188e4bf5bf7e54409d90ba2b
Source dataset
uspto-grants-2016_01
Patent number
US09233978B2

Linked notes

Loading…