Uric Acid → 7,9-Dihydro-1H-purine-2,6,8(3H)-trione, monosodium salt

HRID 590946

Reaction equation

HRID 590946 reaction equation
[NH:1]1[C:11](=[O:12])[C:10]2[NH:9][C:7](=[O:8])[NH:6][C:5]=2[NH:4][C:2]1=[O:3].[OH-].[Na+:14]>>[C:10]12[NH:9][C:7](=[O:8])[N-:6][C:5]=1[NH:4][C:2]([NH:1][C:11]2=[O:12])=[O:3].[Na+:14]

Participants

3

Reactant 2

HCID 1175Uric AcidHCID 14798Sodium Hydroxide2×

Product 1

HCID 236978167,9-Dihydro-1H-purine-2,6,8(3H)-trione, monosodium salt

Conditions

Temperature
70 °C

Procedure

Monosodium urate (MSU) crystals were prepared by dissolving 1.68 g of uric acid in 500 mL of 0.01 M NaOH and heating to 70° C.55,56 NaOH was added as required to maintain the pH between 7.1 and 7.2 and the solution was filtered and incubated at room temperature with slow stirring for 24 hours.

Workup

  1. temperatureto maintain the pH between 7.1 and 7.2
  2. filtrationthe solution was filtered
  3. customincubated at room temperature

Sources & evidence

ORD record
ord-5602e7726f004a31bc1863d79fabac39
Source dataset
uspto-grants-2016_01
Patent number
US09238018B2

Linked notes

Loading…