Ethoxalyl chloride → Ethyl 3,5-dibromo-alpha-oxo-2-thiopheneacetate

HRID 590973

Reaction equation

HRID 590973 reaction equation
[Cl-].[Al+3].[Cl-].[Cl-].[Br:5][C:6]1[S:7][CH:8]=[C:9]([Br:11])[CH:10]=1.Cl[C:13](=[O:19])[C:14]([O:16][CH2:17][CH3:18])=[O:15]>ClCCl>[Br:11][C:9]1[CH:10]=[C:6]([Br:5])[S:7][C:8]=1[C:13](=[O:19])[C:14]([O:16][CH2:17][CH3:18])=[O:15]

Participants

5

Reactant 3

HCID 20884Ethoxalyl chlorideHCID 2724560Thiophene, 2,4-dibromo-HCID 6451240Aluminum(III) Chloride

Product 1

HCID 14113379Ethyl 3,5-dibromo-alpha-oxo-2-thiopheneacetateYield 100%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Aluminium chloride (0.26 g, 1.98 mmol) was added to a solution of 2,4-dibromothiophene (0.30 g, 1.24 mmol) and ethyl chlorooxoacetate (0.19 g, 1.36 mmol) in dichloromethane (10 mL) previously cooled with an ice bath. The reaction mixture was stirred at room temperature for 45 minutes, poured into ice water and extracted with dichloromethane (2×20 mL). The organic layer was dried over sodium sulfate, filtered and concentrated in vacuo to provide ethyl 2-(3,5-dibromothiophen-2-yl)-2-oxoacetate (0.42 g, 1.24 mmol, 100%) as a yellow oil.

Workup

  1. temperaturepreviously cooled with an ice bath
  2. extractionextracted with dichloromethane (2×20 mL)
  3. dry with materialThe organic layer was dried over sodium sulfate
  4. filtrationfiltered
  5. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-ae7a846fa50d4a208d75bab34ff32e62
Source dataset
uspto-grants-2016_01
Patent number
US09238026B2

Linked notes

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