Sulfuric Acid → Benzamide, 2-chloro-6-methyl-

HRID 59271

Reaction equation

HRID 59271 reaction equation
[Cl:1][C:2]1[CH:9]=[CH:8][CH:7]=[C:6]([CH3:10])[C:3]=1[C:4]#[N:5].S(=O)(=O)(O)[OH:12]>>[Cl:1][C:2]1[CH:9]=[CH:8][CH:7]=[C:6]([CH3:10])[C:3]=1[C:4]([NH2:5])=[O:12]

Participants

3

Reactant 2

HCID 1118Sulfuric AcidHCID 230532-Chloro-6-methylbenzonitrile

Product 1

HCID 113589Benzamide, 2-chloro-6-methyl-

Procedure

A solution of 2-chloro-6-methylbenzonitrile (2.0 g) in conc. sulphuric acid (10 mL) was heated at 100° C. for 3-4 h. The reaction mass was quenched in ice-water and the solid obtained was filtered. The precipitate was suck dried to afford 1.5 g of desired product. 1H NMR (300 MHz, DMSO d6): δ 2.28 (s, 3H), 7.21-7.27 (m, 3H), 7.65 (s, 1H), 7.91 (s, 1H).

Workup

  1. customThe reaction mass was quenched in ice-water
  2. customthe solid obtained
  3. filtrationwas filtered
  4. customdried

Sources & evidence

ORD record
ord-c73b4c28bd114f4eaebec7cbf5409d6d
Source dataset
uspto-grants-2016_09
Patent number
US09439890B2

Linked notes

Loading…