Sodium Hydroxide → 2,2'-(Thiobis(methylene))bis(oxirane)

Temperature

5 °C

Next, without isolation, bis(3-chloro-2-hydroxypropyl)sulfide described above was dripped into a reaction vessel containing a mixed solvent consisting of 410 g of toluene and 260 g of 32% aqueous solution of sodium hydroxide with the temperature of the solution in the reaction vessel being maintained at 0 to 10° C. At the point of the completion, no scum-like insoluble matter was generated. The aqueous layer was removed, and the organic layer was washed with 180 g of water three times. After that, no scum-like insoluble matter was generated. After that, the solvent was distilled away, thereby obtaining 138 g (total yield: 95%) of bis(β-epoxypropyl)sulfide.

1. customabove was dripped into a reaction vessel
2. additioncontaining a mixed solvent
3. customThe aqueous layer was removed
4. washthe organic layer was washed with 180 g of water three times
5. distillationAfter that, the solvent was distilled away

ORD record

ord-27d7b883c2c14d47b0241941c491005f

Source dataset

uspto-grants-2016_01

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US09242947B2