Sulfuric Acid → 5-((2,2,2-Trifluoroacetamido)methyl)-2-chloro-4-methoxybenzoic acid

HRID 59369

Reaction equation

HRID 59369 reaction equation
[Cl:1][C:2]1[CH:10]=[C:9]([O:11][CH3:12])[CH:8]=[CH:7][C:3]=1[C:4]([OH:6])=[O:5].[F:13][C:14]([F:21])([F:20])[C:15]([NH:17][CH2:18]O)=[O:16].OS(O)(=O)=O>>[F:13][C:14]([F:21])([F:20])[C:15]([NH:17][CH2:18][C:8]1[C:9]([O:11][CH3:12])=[CH:10][C:2]([Cl:1])=[C:3]([CH:7]=1)[C:4]([OH:6])=[O:5])=[O:16]

Participants

4

Reactant 3

HCID 1118Sulfuric AcidHCID 30849312,2,2-Trifluoro-N-(hydroxymethyl)acetamideHCID 126480262-Chloro-4-methoxybenzoic acid

Product 1

HCID 900194215-((2,2,2-Trifluoroacetamido)methyl)-2-chloro-4-methoxybenzoic acidYield 39.9%

Procedure

The title compound was prepared according to the procedure described in step-1 of Intermediate-26 by using 2-chloro-4-methoxybenzoic acid (0.060 g), 2,2,2-trifluoro-N-(hydroxymethyl)acetamide (0.050 g) and H2SO4 (2 mL) to afford 0.040 g of the desired product.

Workup

  1. customThe title compound was prepared

Sources & evidence

ORD record
ord-28def1e1d84f42db8ac98d0a93fae888
Source dataset
uspto-grants-2016_09
Patent number
US09439890B2

Linked notes

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