(2,2'-Bipyridine)-6-carbaldehyde → 1-([2,2'-Bipyridin]-6-ylmethyl)-6-(2,6-dimethoxyphenyl)piperidin-2-one

HRID 594456Notes

Reaction equation

HRID 594456 reaction equation
[NH2:1][CH:2]([C:10]1[C:15]([O:16][CH3:17])=[CH:14][CH:13]=[CH:12][C:11]=1[O:18][CH3:19])[CH2:3][CH2:4][CH2:5][C:6]([O:8]C)=O.[N:20]1[C:25]([CH:26]=O)=[CH:24][CH:23]=[CH:22][C:21]=1[C:28]1[CH:33]=[CH:32][CH:31]=[CH:30][N:29]=1>>[N:20]1[C:25]([CH2:26][N:1]2[CH:2]([C:10]3[C:15]([O:16][CH3:17])=[CH:14][CH:13]=[CH:12][C:11]=3[O:18][CH3:19])[CH2:3][CH2:4][CH2:5][C:6]2=[O:8])=[CH:24][CH:23]=[CH:22][C:21]=1[C:28]1[CH:33]=[CH:32][CH:31]=[CH:30][N:29]=1

Participants

3

Reactant 2

HCID 11095276(2,2'-Bipyridine)-6-carbaldehydeHCID 69082713Methyl 5-amino-5-(2,6-dimethoxyphenyl)pentanoate

Product 1

HCID 690857301-([2,2'-Bipyridin]-6-ylmethyl)-6-(2,6-dimethoxyphenyl)piperidin-2-one

Procedure

Prepared according to the described general procedure 1 (GP1) by reaction of methyl 5-amino-5-(2,6-dimethoxyphenyl)pentanoate with [2,2′-bipyridine]-6-carbaldehyde. Subsequent purification by preparative HPLC afforded the target compound. LC-MS (conditions A): tR=0.58 min.; [M+H]+: 403.99 g/mol.

Workup

  1. customPrepared
  2. customSubsequent purification by preparative HPLC
  3. customafforded the target compound

Sources & evidence

ORD record
ord-cadc240fe5254533860205f63aefa8e5
Source dataset
uspto-grants-2016_01
Patent number
US09242970B2

Reaction notes

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