HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sulfuric Acid → isopropyl 5-fluoro-3-methyl-1H-indole-2-propanoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sulfuric Acid | HCID 1118 | — |
| Reactant | 4-Fluorophenylhydrazine hydrochloride | HCID 69981 | — |
| Reactant | Sodium Bicarbonate | HCID 516892 | — |
| Reactant | Ethyl 4-oxohexanoate | HCID 12271528 | — |
| Solvent | Isopropanol | HCID 3776 | — |
| Product | isopropyl 5-fluoro-3-methyl-1H-indole-2-propanoate | HCID 19794669 | — |
Reaction Steps
A mixture of 1-(4-fluorophenyl)hydrazine hydrochloride (1.03 g), ethyl 4-oxo-hexanoate (1.0 g), 2-propanol (25 ml) and H2SO4 is refluxed under nitrogen for 9 hours. After cooling the mixture is poured into a aqueous solution of NaHCO3, extracted with AcOEt and evaporated to dryness to yield 1.45 g of isopropyl 5-fluoro-3-methyl-1H-indole-2-propanoate.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05246957 |
| Source dataset | uspto-grants-1993_09 |
| ORD ID | ord-7032a768e4ff40098e40773662a0af2f |
| Source note | uspto-grants-1993_09 |