Methyl 6-amino-6-(2,6-dimethoxyphenyl)hexanoate → 1-((5-Chloro-6-(difluoromethoxy)pyridin-3-yl)methyl)-7-(2,6-dimethoxyphenyl)azepan-2-one
Reaction equation
[NH2:1][CH:2]([C:11]1[C:16]([O:17][CH3:18])=[CH:15][CH:14]=[CH:13][C:12]=1[O:19][CH3:20])[CH2:3][CH2:4][CH2:5][CH2:6][C:7]([O:9]C)=O.[Cl:21][C:22]1[C:23]([O:30][CH:31]([F:33])[F:32])=[N:24][CH:25]=[C:26]([CH:29]=1)[CH:27]=O>>[Cl:21][C:22]1[CH:29]=[C:26]([CH2:27][N:1]2[CH:2]([C:11]3[C:16]([O:17][CH3:18])=[CH:15][CH:14]=[CH:13][C:12]=3[O:19][CH3:20])[CH2:3][CH2:4][CH2:5][CH2:6][C:7]2=[O:9])[CH:25]=[N:24][C:23]=1[O:30][CH:31]([F:33])[F:32]Participants
3
Procedure
Prepared according to the described general procedure 1 (GP1) by reaction of methyl 6-amino-6-(2,6-dimethoxyphenyl)hexanoate with 5-chloro-6-(difluoromethoxy)nicotinaldehyde. Subsequent purification by preparative HPLC afforded the target compound. LC-MS (conditions A): tR=0.94 min.; [M+H]+: 441.11 g/mol.
Workup
- customPrepared
- customSubsequent purification by preparative HPLC