Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 594702Generated: October 27, 2026

3-(Trifluoromethoxy)benzaldehyde → 5-(2-Ethoxy-6-fluorophenyl)-3-methyl-1-(3-(trifluoromethoxy)benzyl)pyrrolidin-2-one

https://huagongshe.com/reaction/594702

Reaction equation

Participants

RoleNameHCIDCharge
Reactant3-(Trifluoromethoxy)benzaldehydeHCID 605139—
ReactantEthyl 4-amino-4-(2-ethoxy-6-fluorophenyl)-2-methylbutanoateHCID 69083532—
Product5-(2-Ethoxy-6-fluorophenyl)-3-methyl-1-(3-(trifluoromethoxy)benzyl)pyrrolidin-2-oneHCID 69085153—

Reaction Steps

Prepared according to the described general procedure 2 (GP2) by reaction of ethyl 4-amino-4-(2-ethoxy-6-fluorophenyl)-2-methylbutanoate with commercially available 3-(trifluoromethoxy)benzaldehyde. Subsequent purification by preparative HPLC afforded the target compound. LC-MS (conditions A): tR=0.97 min.; [M+H]+: 411.84 g/mol.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09242970B2
Source datasetuspto-grants-2016_01
ORD IDord-b29566f00bca4e3fa8c8d8d76d48caf2
Source noteuspto-grants-2016_01