4-Methoxy-3-(trifluoromethoxy)benzaldehyde → HCID 69081747, compound
Reaction equation
[NH2:1][CH:2]([C:11]1[C:16]([O:17][CH3:18])=[CH:15][CH:14]=[CH:13][C:12]=1[O:19][CH3:20])[CH2:3][CH:4]([CH3:10])[C:5]([O:7]CC)=O.[CH3:21][O:22][C:23]1[CH:30]=[CH:29][C:26]([CH:27]=O)=[CH:25][C:24]=1[O:31][C:32]([F:35])([F:34])[F:33]>>[CH3:18][O:17][C:16]1[CH:15]=[CH:14][CH:13]=[C:12]([O:19][CH3:20])[C:11]=1[CH:2]1[N:1]([CH2:27][C:26]2[CH:29]=[CH:30][C:23]([O:22][CH3:21])=[C:24]([O:31][C:32]([F:33])([F:34])[F:35])[CH:25]=2)[C:5](=[O:7])[CH:4]([CH3:10])[CH2:3]1Participants
3
Procedure
Prepared according to the described general procedure 2 (GP2) by reaction of ethyl 4-amino-4-(2,6-dimethoxyphenyl)-2-methylbutanoate with commercially available 4-methoxy-3-(trifluoromethoxy)benzaldehyde. Subsequent purification by preparative HPLC afforded the target compound. LC-MS (conditions A): tR=0.91 min.; [M+H]+: 439.85 g/mol.
Workup
- customPrepared
- customSubsequent purification by preparative HPLC
- customafforded the target compound