Morpholine → (4-Amino-1-methyl-1H-pyrrol-2-yl)(morpholin-4-yl)methanone

Reaction equation

[CH3:1][N:2]1[CH:6]=[C:5]([N+:7]([O-])=O)[CH:4]=[C:3]1[C:10]([OH:12])=O.[NH:13]1[CH2:18][CH2:17][O:16][CH2:15][CH2:14]1>>[NH2:7][C:5]1[CH:4]=[C:3]([C:10]([N:13]2[CH2:18][CH2:17][O:16][CH2:15][CH2:14]2)=[O:12])[N:2]([CH3:1])[CH:6]=1

Participants

Reactant 2

HCID 8083Morpholine

HCID 27369151-Methyl-4-nitropyrrole-2-carboxylic acid

Product 1

HCID 43641895(4-Amino-1-methyl-1H-pyrrol-2-yl)(morpholin-4-yl)methanone

Procedure

(4-amino-1-methyl-1H-pyrrol-2-yl)(morpholino)methanone was prepared as in Example 239 (Steps i-ii) using 1-methyl-4-nitro-1H-pyrrole-2-carboxylic acid and morpholine:

Sources & evidence

ORD record: ord-0a1108a4c6de4fe59f5b4da8c7baef87
Source dataset: uspto-grants-2016_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09242987B2

Reaction notes

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