Chloroacetyl chloride → 1H-1,4-Benzodiazepine

HRID 596360

Reaction equation

HRID 596360 reaction equation
Cl[C:2]1[CH:3]=[CH:4][C:5]2[N:11]=[C:10](NN)[CH2:9][N:8]=[C:7](C3C(F)=CC=CC=3F)[C:6]=2[CH:22]=1.ClCC(Cl)=O.C([O-])(=O)C.[Na+]>>[NH:11]1[C:5]2[CH:4]=[CH:3][CH:2]=[CH:22][C:6]=2[CH:7]=[N:8][CH:9]=[CH:10]1

Participants

4

Reactant 3

HCID 6577Chloroacetyl chlorideHCID 517045Sodium AcetateHCID 20291823HCID 20291823, compound

Product 1

HCID 1484311H-1,4-Benzodiazepine

Procedure

In the manner given in Preparation 10, 7-chloro-5(2,6-difluorophenyl)-3H-1,4-benzodiazepin-2-yl hydrazine is reacted with chloroacetyl chloride and after 1.5 hours with sodium acetate, then the mixture is refluxed to give 8-chloro-1-(chloromethyl)-6-(2,6-difluorophenyl)-4H-s-triazolo[4,3-a][1,4-benzodiazepine. Preparation 14 8-Nitro-1-(bromomethyl)-6-(o-chlorophenyl)-4H-s-triazolo[4,3-a][1,4]benzodiazepine

Workup

  1. temperaturethe mixture is refluxed

Sources & evidence

ORD record
ord-e1ceb363288a48ba9780f4b7d7d00abc
Source dataset
uspto-grants-1977_03
Patent number
US04010177

Linked notes

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