Formaldehyde → Benzophenone

HRID 596397

Reaction equation

HRID 596397 reaction equation
Cl[C:2]1[CH:3]=[CH:4][C:5]2N3C(CN(CC4CC4)C)=NN=C3CN=[C:7]([C:22]3[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=3)[C:6]=2[CH:28]=1.C=[O:30]>C(O)=O>[C:7]([C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1)(=[O:30])[C:6]1[CH:5]=[CH:4][CH:3]=[CH:2][CH:28]=1

Participants

4

Reactant 2

HCID 712FormaldehydeHCID 126124338-chloro-1-[[(cyclopropylmethyl)methylamino]methyl]-6-phenyl-4H-s-triazolo[4,3-a][1,4]benzodiazepine

Product 1

HCID 3102Benzophenone

Reagents, catalysts & solvents 1

HCID 284Formic AcidSolvent

Procedure

In the manner given in Example 1, 8-chloro-1-[[(cyclopropylmethyl)methylamino]methyl]-6-phenyl-4H-s-triazolo[4,3-a][1,4]benzodiazepine is heated in formic acid with aqueous formaldehyde to give 5-chloro-2-[3-[[(cyclopropylmethyl)methylamino]methyl]-5-](dimethylamino)methyl]-4-H-1,2,4-triazol-4-yl]benzophenone. This product is identical to that given in Example 21.

Sources & evidence

ORD record
ord-d54cecf16a37440894662ab6834afba9
Source dataset
uspto-grants-1977_03
Patent number
US04010177

Linked notes

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