2,6-Dimethyl-1-piperidineethanamine → N-Propionyl-N'[2-(2,6-dimethylpiperidino)-ethyl]thiourea

HRID 596595

Reaction equation

[NH2:1][CH2:2][CH2:3][N:4]1[CH:9]([CH3:10])[CH2:8][CH2:7][CH2:6][CH:5]1[CH3:11].[C:12]([N:16]=[C:17]=[S:18])(=[O:15])[CH2:13][CH3:14]>>[C:12]([NH:16][C:17]([NH:1][CH2:2][CH2:3][N:4]1[CH:9]([CH3:10])[CH2:8][CH2:7][CH2:6][CH:5]1[CH3:11])=[S:18])(=[O:15])[CH2:13][CH3:14]

Participants

Reactant 2

HCID 31492662,6-Dimethyl-1-piperidineethanamine

HCID 12745460Propanecarbonyl isothiocyanate

Product 1

HCID 21450385N-Propionyl-N'[2-(2,6-dimethylpiperidino)-ethyl]thiourea

Procedure

By the general method described in Example 1, 1-(2-aminoethyl)-2,6-dimethylpiperidine is reacted with propionyl isothiocyanate to give the title compound which may be hydrolysed with 10% sodium hydroxide to give N-2[(2,6-dimethylpiperidino)-ethyl]thiourea.

Sources & evidence

ORD record: ord-70cb36cfcf14437188958fd6dcde8d3c
Source dataset: uspto-grants-1977_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04011331

Linked notes

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