HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrogen Bromide → L-tryptophanyl-L-methionyl-L-aspartyl-DL-norvaline amide hydrobromide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrogen Bromide | HCID 260 | — |
| Reactant | N-benzyloxycarbonyl-L-tryptophanyl-L-methionyl-L-aspartyl-DL-norvaline amide | HCID 22796407 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Solvent | Ethyl methyl sulfide | HCID 12230 | — |
| Product | L-tryptophanyl-L-methionyl-L-aspartyl-DL-norvaline amide hydrobromide | HCID 22796390 | — |
Reaction Steps
N-benzyloxycarbonyl-L-tryptophanyl-L-methionyl-L-aspartyl-DL-norvaline amide is dissolved in 10 parts glacial acetic acid containing 2 parts methylethyl sulfide. Then, 10 parts of 6 M hydrobromic acid in acetic acid is added and the solution is allowed to stand for one hour at room temperature. The solvents are removed under vacuum below 40° C. and the residue shaken with ether to afford L-tryptophanyl-L-methionyl-L-aspartyl-DL-norvaline amide hydrobromide. This compound is represented by the following formula.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04012367 |
| Source dataset | uspto-grants-1977_03 |
| ORD ID | ord-8ac2eeb5e3e447358b5e3ac14dbce5f5 |
| Source note | uspto-grants-1977_03 |