Reaction equation
O.Cl.[NH2:3][C@H:4]([C:9]([NH:11][C@H:12]([C:17]([CH2:19][C:20]([NH2:28])([CH3:27])[C:21]([NH:23][CH2:24][CH2:25][CH3:26])=[O:22])=[O:18])[CH2:13][C:14](=[O:16])[OH:15])=[O:10])[CH2:5][CH2:6][S:7][CH3:8].[C:29]([O:33][C:34]([NH:36][C@H:37]([C:48](N[C@H](C(N[C@H](C(N[C@@H](C(N)=O)C)=O)CC(=O)O)=O)CCSC)=[O:49])[CH2:38][C:39]1[C:47]2[C:42](=[CH:43][CH:44]=[CH:45][CH:46]=2)[NH:41][CH:40]=1)=[O:35])([CH3:32])([CH3:31])[CH3:30]>>[C:29]([O:33][C:34]([NH:36][C@H:37]([C:48]([NH:3][C@H:4]([C:9]([NH:11][C@H:12]([C:17]([CH2:19][C:20]([NH2:28])([CH3:27])[C:21]([NH:23][CH2:24][CH2:25][CH3:26])=[O:22])=[O:18])[CH2:13][C:14](=[O:15])[OH:16])=[O:10])[CH2:5][CH2:6][S:7][CH3:8])=[O:49])[CH2:38][C:39]1[C:47]2[C:42](=[CH:43][CH:44]=[CH:45][CH:46]=2)[NH:41][CH:40]=1)=[O:35])([CH3:31])([CH3:32])[CH3:30]Participants
3
Reactant 2
Product 1
Procedure
When an equivalent quantity of L-methionyl-L-aspartyl-N1 -propyl-2-amino-2-methylpropionamide hydrochloride hydrate is substituted for the L-methionyl-L-aspartyl-D-alanine amide hydrochloride of Example 6, and the procedure detailed therein substantially repeated, there is obtained N-t-butoxycarbonyl-L-tryptophanyl-L-methionyl-L-aspartyl-N1 -propyl-2-amino-2-methylpropionamide hydrated with 2/3 mole of water per mole. Actual elemental analysis shows C: 55.82%; H: 7.21%; N: 12.37% and S: 4.72%. Theoretical elemental analysis is C: 55.79%; H: 7.22%; N: 12.20% and S: 4.66%. This compound is represented by the following formula. ##STR17##
Sources & evidence
- ORD record
- ord-5e54c9aa9fb34732b7e0d633c727d277
- Source dataset
- uspto-grants-1977_03
- Patent number
- US04012367
Linked notes
Loading…