Borane → 1H-1,4-Benzodiazepine

HRID 597078

Reaction equation

C(N(CC)C(=O)CC1[N:10]2[C:11]3[CH:27]=[CH:26][C:25](F)=[CH:24][C:12]=3[C:13](C3C=CC=CC=3F)=[N:14][CH:15](C)[C:9]2=NN=1)C.B>>[NH:10]1[C:11]2[CH:27]=[CH:26][CH:25]=[CH:24][C:12]=2[CH:13]=[N:14][CH:15]=[CH:9]1

Participants

Reactant 2

HCID 6331Borane

HCID 21449044HCID 21449044, compound

Product 1

HCID 1484311H-1,4-Benzodiazepine

Procedure

In the manner given in Example 1, N,N-diethyl-4-methyl-8-fluoro-6-(o-fluorophenyl)-4H-s-triazolo[4,3-a]-[1,4]benzodiazepine-1-acetamide is reduced with borane to give 1-[2-diethylamino)ethyl]-4-methyl-8-fluoro-5,6-dihydro-6-(o-fluorophenyl)-4H-s-triazolo]4,3-a][1,4]benzodiazepine.

Sources & evidence

ORD record: ord-f28aa78997034200b083d17358eb3950
Source dataset: uspto-grants-1977_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04012413

Linked notes

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