Methanol → HCID 178441961, compound

HRID 597146

Reaction equation

HRID 597146 reaction equation
Br[C:2](Br)([C:6]([CH3:9])([CH3:8])[CH3:7])[C:3](O)=[O:4].[NH2:11][NH:12][C:13]([NH:15][NH2:16])=[S:14].CO>O>[NH2:16][N:15]1[C:3](=[O:4])[C:2]([C:6]([CH3:9])([CH3:8])[CH3:7])=[N:11][N:12]=[C:13]1[SH:14]

Participants

5

Reactant 3

HCID 887MethanolHCID 2724189ThiocarbohydrazideHCID 214468942,2-Dibromo-3,3-dimethylbutyric acid

Product 1

HCID 178441961HCID 178441961, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
0 °C

Procedure

A mixture of 2,2-dibromo-3,3-dimethylbutyric acid, 55 parts, and thiocarbohydrazide, 22 parts, in 500 parts of (1:1) methanol and water was heated to reflux for five hours. Upon cooling the reaction mixture to 0° C., a solid formed and was collected. The solid, 4-amino-6-t-butyl-3-mercapto-1,2,4-triazin-5-one, was obtained in 78% of theory (29 parts).

Workup

  1. temperatureto reflux for five hours
  2. customa solid formed
  3. customwas collected

Sources & evidence

ORD record
ord-e22668be1d1948199e90abab48666f87
Source dataset
uspto-grants-1977_03
Patent number
US04013649

Linked notes

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