2,2,2-Trifluoroethyl 2,5-bis(2,2,2-trifluoroethoxy)benzoate → N-[1-(Piperidin-2-yl)ethyl]-2,5-bis(2,2,2-trifluoroethoxy)benzamide

HRID 597223

Reaction equation

HRID 597223 reaction equation
[F:1][C:2]([F:26])([F:25])[CH2:3][O:4][C:5]1[CH:18]=[CH:17][C:16]([O:19][CH2:20][C:21]([F:24])([F:23])[F:22])=[CH:15][C:6]=1[C:7]([O:9]CC(F)(F)F)=O.[NH2:27][CH:28]([CH:30]1[CH2:35][CH2:34][CH2:33][CH2:32][NH:31]1)[CH3:29]>>[F:26][C:2]([F:1])([F:25])[CH2:3][O:4][C:5]1[CH:18]=[CH:17][C:16]([O:19][CH2:20][C:21]([F:24])([F:22])[F:23])=[CH:15][C:6]=1[C:7]([NH:27][CH:28]([CH:30]1[CH2:35][CH2:34][CH2:33][CH2:32][NH:31]1)[CH3:29])=[O:9]

Participants

3

Reactant 2

HCID 112810142,2,2-Trifluoroethyl 2,5-bis(2,2,2-trifluoroethoxy)benzoateHCID 21890255(1-Piperidin-2-ylethyl)amine

Product 1

HCID 21447146N-[1-(Piperidin-2-yl)ethyl]-2,5-bis(2,2,2-trifluoroethoxy)benzamide

Procedure

Starting with 2,2,2-trifluoroethyl 2,5-bis(2,2,2-trifluoroethoxy)benzoate and 2-(1-aminoethyl)piperidine and using the procedure illustrated in Examples 21 and 22, the product 2,5-bis(2,2,2-trifluoroethoxy)-N-[1-(2-piperidyl)ethyl]-benzamide, m.p. 95°-97° C., is obtained as white needles.

Sources & evidence

ORD record
ord-dd72badaf4734cb0ae53f147f94f4c90
Source dataset
uspto-grants-1977_03
Patent number
US04013670

Linked notes

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