2-Aminomethyl-1-ethylpyrrolidine → 2,5-bis(2,2,2-trifluoroethoxy)-N-[(1-ethyl-2-pyrrolidyl)methyl]benzamide

HRID 597224

Reaction equation

HRID 597224 reaction equation
[CH2:1]([N:3]1[CH2:7][CH2:6][CH2:5][CH:4]1[CH2:8][NH2:9])[CH3:2].[F:10][C:11]([F:35])([F:34])[CH2:12][O:13][C:14]1[CH:27]=[CH:26][C:25]([O:28][CH2:29][C:30]([F:33])([F:32])[F:31])=[CH:24][C:15]=1[C:16](OCC(F)(F)F)=[O:17]>>[F:10][C:11]([F:34])([F:35])[CH2:12][O:13][C:14]1[CH:27]=[CH:26][C:25]([O:28][CH2:29][C:30]([F:33])([F:32])[F:31])=[CH:24][C:15]=1[C:16]([NH:9][CH2:8][CH:4]1[CH2:5][CH2:6][CH2:7][N:3]1[CH2:1][CH3:2])=[O:17]

Participants

3

Reactant 2

HCID 1172952-Aminomethyl-1-ethylpyrrolidineHCID 112810142,2,2-Trifluoroethyl 2,5-bis(2,2,2-trifluoroethoxy)benzoate

Product 1

HCID 541427402,5-bis(2,2,2-trifluoroethoxy)-N-[(1-ethyl-2-pyrrolidyl)methyl]benzamide

Procedure

Using the synthetic method illustrated in Example 23, 1-ethyl-2-aminomethyl pyrrolidine and 2,2,2-trifluoroethyl 2,5-bis(2,2,2-trifluoroethoxy)benzoate are reacted to provide a white solid, 2,5-bis(2,2,2-trifluoroethoxy)-N-[(1-ethyl-2-pyrrolidyl)methyl]benzamide, m.p. 78°-80° C.

Workup

  1. customare reacted

Sources & evidence

ORD record
ord-ed1c837ddfe04296a6eb2bf2afabceab
Source dataset
uspto-grants-1977_03
Patent number
US04013670

Linked notes

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