Benzeneacetonitrile, 4-methoxy- → 5-[2-(2-Fluoro-phenyl)-2H-pyrazol-3-yl]-3-(4-methoxy-phenyl)-benzo[c]isoxazole

HRID 59822

Reaction equation

HRID 59822 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[N:8]1[C:12]([C:13]2[CH:18]=[CH:17][C:16]([N+:19]([O-:21])=O)=[CH:15][CH:14]=2)=[CH:11][CH:10]=[N:9]1.[CH3:22][O:23][C:24]1[CH:29]=[CH:28][C:27]([CH2:30]C#N)=[CH:26][CH:25]=1>>[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[N:8]1[C:12]([C:13]2[CH:14]=[CH:15][C:16]3=[N:19][O:21][C:30]([C:27]4[CH:28]=[CH:29][C:24]([O:23][CH3:22])=[CH:25][CH:26]=4)=[C:17]3[CH:18]=2)=[CH:11][CH:10]=[N:9]1

Participants

3

Reactant 2

HCID 66031Benzeneacetonitrile, 4-methoxy-HCID 900327651-(2-fluoro-phenyl)-5-(4-nitro-phenyl)-1H-pyrazole2×

Product 1

HCID 730528475-[2-(2-Fluoro-phenyl)-2H-pyrazol-3-yl]-3-(4-methoxy-phenyl)-benzo[c]isoxazole

Procedure

The title compound, light yellow solid (27 mg, 20%), MS (ISP) m/z=386.3 [(M+H)+], mp 134° C., was prepared in accordance with the general method of example 1 from 1-(2-fluoro-phenyl)-5-(4-nitro-phenyl)-1H-pyrazole (intermediate B) (100 mg, 353 μmol) and commercially available 2-(4-methoxy-phenyl)-acetonitrile.

Sources & evidence

ORD record
ord-b8f00a84dd0b44fca395ed7b1a00ea85
Source dataset
uspto-grants-2016_09
Patent number
US09440962B2

Linked notes

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