Potassium ethylxanthate → HCID 178505601, compound
Reaction equation
[NH2:1][C:2]1[C:7]([F:8])=[CH:6][CH:5]=[CH:4][C:3]=1[OH:9].CCO[C:13]([S-])=[S:14].[K+]>CO>[F:8][C:7]1[C:2]2[N:1]=[C:13]([SH:14])[O:9][C:3]=2[CH:4]=[CH:5][CH:6]=1Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 70 °C
Procedure
A mixture of 1 g (7.867 mmol) 2-amino-3-fluorophenol and 1.42 g (8.654 mmol) potassium ethylxanthogenate in 28 mL methanol was heated in a 70° C. oil bath for 3 h. The solvent was removed in vacuo. The residue was dissolved in 50 mL water. The aqueous layer was acidified with HCl 2N. The solid was filtered, washed with water and dried to provide 568 mg (42.7%) of the title compound as a light grey solid. MS(m/e): 168.0 (M−H+).
Workup
- customThe solvent was removed in vacuo
- dissolutionThe residue was dissolved in 50 mL water
- filtrationThe solid was filtered
- washwashed with water
- customdried
Sources & evidence
- ORD record
- ord-eb344cf9a5754001af6c2f36b5311ef4
- Source dataset
- uspto-grants-2011_03
- Patent number
- US07897627B2
Reaction notes
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