Methyl 3-cyano-4-fluorobenzoate → Methyl 3-(aminomethyl)-4-fluorobenzoate hydrochloride

HRID 59893

Reaction equation

HRID 59893 reaction equation
[C:1]([C:3]1[CH:4]=[C:5]([CH:10]=[CH:11][C:12]=1[F:13])[C:6]([O:8][CH3:9])=[O:7])#[N:2].[ClH:14].NCC1C=C(C=C(OC)C=1)C(OC)=O>>[ClH:14].[NH2:2][CH2:1][C:3]1[CH:4]=[C:5]([CH:10]=[CH:11][C:12]=1[F:13])[C:6]([O:8][CH3:9])=[O:7]

Participants

3

Reactant 2

HCID 45790123Methyl 3-cyano-4-fluorobenzoateHCID 118366264Methyl 3-(aminomethyl)-5-methoxybenzoate hydrochloride

Product 1

HCID 75422100Methyl 3-(aminomethyl)-4-fluorobenzoate hydrochloride

Procedure

Methyl 3-(aminomethyl)-4-fluorobenzoate hydrochloride was prepared from methyl 3-cyano-4-fluorobenzoate in an analogous manner to Intermediate 2.

Sources & evidence

ORD record
ord-ce4bc81a61f34d54a95de13d3fa8705e
Source dataset
uspto-grants-2016_09
Patent number
US09440949B2

Linked notes

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