Ethyl 5-Cyano-6-methylnicotinate → Ethyl 5-(aminomethyl)-6-methylnicotinate

HRID 59898

Reaction equation

HRID 59898 reaction equation
[C:1]([C:3]1[C:4]([CH3:14])=[N:5][CH:6]=[C:7]([CH:13]=1)[C:8]([O:10][CH2:11][CH3:12])=[O:9])#[N:2].Cl.NCC1C=C(C=C(OC)C=1)C(OC)=O>>[NH2:2][CH2:1][C:3]1[C:4]([CH3:14])=[N:5][CH:6]=[C:7]([CH:13]=1)[C:8]([O:10][CH2:11][CH3:12])=[O:9]

Participants

3

Reactant 2

HCID 13600369Ethyl 5-Cyano-6-methylnicotinateHCID 118366264Methyl 3-(aminomethyl)-5-methoxybenzoate hydrochloride

Product 1

HCID 118366162Ethyl 5-(aminomethyl)-6-methylnicotinate

Procedure

Ethyl 5-(aminomethyl)-6-methylnicotinate was prepared from ethyl 5-cyano-6-methylnicotinate in an analogous manner to Intermediate 2.

Sources & evidence

ORD record
ord-3470d1c451f5445a82da832aa378c097
Source dataset
uspto-grants-2016_09
Patent number
US09440949B2

Linked notes

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