Benzenemethanamine, 4-chloro-3-(trifluoromethyl)- → 4-((4-Chloro-3-(trifluoromethyl)benzyl)amino)benzo[d][1,2,3]triazine-8-carboxamide

Participants

Role	Name	HCID	Charge
Reactant	Benzenemethanamine, 4-chloro-3-(trifluoromethyl)-	HCID 485440	—
Reactant	4-oxo-1H-1,2,3-benzotriazine-8-carboxamide	HCID 178513613	—
Product	4-((4-Chloro-3-(trifluoromethyl)benzyl)amino)benzo[d][1,2,3]triazine-8-carboxamide	HCID 76073575	—

Reaction Steps

Compound 4 was prepared following general synthetic scheme 7 wherein (4-chloro-3-(trifluoromethyl)phenyl)methanamine was reacted with 4-hydroxybenzo[d][1,2,3]-triazine-8-carboxamide to give the title compound. LC-MS [382 (M+1)], 1H NMR (400 MHz, DMSO-d): δ 9.38-9.32 (m, 2H), 8.54 (d, 1H), 8.48 (d, 1H), 8.05 (s, 1H), 8.02-7.98 (m, 1H), 7.95 (s, 1H), 7.73-7.68 (m, 2H), 4.96 (d, 2H).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US09440968B2
Source dataset	uspto-grants-2016_09
ORD ID	ord-33f2834b9c86443388921c0d203f1ac2
Source note	uspto-grants-2016_09