Water → 5-Iodo-2-(methylthio)benzonitrile
Reaction equation
[CH3:1][S-:2].[Na+].F[C:5]1[CH:12]=[CH:11][C:10]([I:13])=[CH:9][C:6]=1[C:7]#[N:8].O>CS(C)=O>[I:13][C:10]1[CH:11]=[CH:12][C:5]([S:2][CH3:1])=[C:6]([CH:9]=1)[C:7]#[N:8]Participants
5
Reactant 3
Product 1
Reagents, catalysts & solvents 1
Procedure
Sodium thiomethoxide (0.142 g) was added to a solution of 2-fluoro-5-iodobenzonitrile (0.5 g) in DMSO (1 mL) and the mixture stirred. An exotherm was noted. After stirring for 90 min, water was added and the solid that precipitated was collected, washed with water and dried at 50° C. under vacuum to leave the subtitle compound as an off-white solid (0.52 g).
Workup
- stirringAfter stirring for 90 min
- customthe solid that precipitated
- customwas collected
- washwashed with water
- customdried at 50° C. under vacuum
Sources & evidence
- ORD record
- ord-5a4a1bb640f549d697a5ac4e26dfa675
- Source dataset
- uspto-grants-2011_03
- Patent number
- US07902181B2
Reaction notes
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