4-Tert-butyl-2-nitrobenzoic acid → 2-Amino-4-tert-butylbenzoic acid
Reaction equation
[C:1]([C:5]1[CH:13]=[CH:12][C:8]([C:9]([OH:11])=[O:10])=[C:7]([N+:14]([O-])=O)[CH:6]=1)([CH3:4])([CH3:3])[CH3:2]>[Pd].C(O)C>[NH2:14][C:7]1[CH:6]=[C:5]([C:1]([CH3:4])([CH3:3])[CH3:2])[CH:13]=[CH:12][C:8]=1[C:9]([OH:11])=[O:10]Participants
4
Reactant 1
Product 1
Reagents, catalysts & solvents 2
Procedure
4-tert-Butyl-2-nitro-benzoic acid (199 mg, 8.91 mmol), and 10% palladium on carbon (40 mg) were stirred in 6 mL ethanol under an atmosphere of hydrogen for 3 hours. The resulting mixture was filtered and concentrated in vacuo to yield 2-Amino-4-tert-butyl-benzoic acid (177 mg, 0.916 mmol).
Workup
- filtrationThe resulting mixture was filtered
- concentrationconcentrated in vacuo
Sources & evidence
- ORD record
- ord-e422b9e77b964f47ae300cabc0da87c4
- Source dataset
- uspto-grants-2011_03
- Patent number
- US07902194B2
Reaction notes
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