Water → 2-(Isoquinolin-7-yloxy)pentanoic acid sodium salt
Reaction equation
O.[OH-].[Na+:3].[CH:4]1[C:13]2[C:8](=[CH:9][CH:10]=[C:11]([O:14][CH:15]([CH2:21][CH2:22][CH3:23])[C:16]([O:18]CC)=[O:17])[CH:12]=2)[CH:7]=[CH:6][N:5]=1>CO>[Na+:3].[CH:4]1[C:13]2[C:8](=[CH:9][CH:10]=[C:11]([O:14][CH:15]([CH2:21][CH2:22][CH3:23])[C:16]([O-:18])=[O:17])[CH:12]=2)[CH:7]=[CH:6][N:5]=1Participants
5
Reactant 3
Product 1
Reagents, catalysts & solvents 1
Procedure
10 ml of water and 840 mg (21.0 mmol) of sodium hydroxide are added to a solution of 5.20 g (19.0 mmol) of ethyl 2-(isoquinolin-7-yloxy) -pentanoate in 50 ml of methanol, and the mixture is stirred at room temperature for 42 hours. The solvent is removed by distillation, giving 2-(isoquinolin-7-yloxy)pentanoic acid sodium salt as a colourless solid; ESI 246.